Hypoglycemic activity of cucumis sativus extract on. Phytochemical composition of the herbal extracts, fasting plasma glucose concentration fpgc, and serum. Effect of doum fruit hyphaene thebaica extract on some. Alloxan and streptozotocin are the most prominent diabetogenic chemicals in diabetes research. Silymarin increases antioxidant enzymes in alloxan induced diabetes in rat pancreas. In this study 36 male wistar rats, body weight of 150200gr were divided into 6 groups. In the in vivo experiment, glucose given to rats 20 min prior to alloxan partially restricted alloxan induced increase in the activity of glutathione peroxidase. Alloxan diabetic rats were orally supplied with kombucha and black tea at a dose of 5 mlkg body weight per day for 30 days, fasted overnight. Fabaceae leaves and flowers on alloxan induced diabetes in rats. Effect of luffa aegyptica leaf extract on blood sugar level in alloxan induced diabetic rats. Induction of diabetes mellitus alloxan monohydrate was used to induce diabetes mellitus. This causes an insulindependent diabetes mellitus called alloxan diabetes in these animals, with characteristics similar to type 1 diabetes in humans. In the alloxan induced diabetic rats showed that extract at 500 mgkg decreased significantly fasting plasma glucose level by 61.
Antidiabetic and antioxidant activities of the methanol. Antihyperglycemic and antihyperlipidemic effect of. The herbal formulation known as herbamed was administered to diabetic rats for 7 days at 0. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal, intravenous and subcutaneous.
Alloxan 150mgkg was used to induce diabetes in rats and the blood glucose levels were estimated by using glucometer. Diabetes was induced with administration of alloxan, 150 mgkg body weight i. Cagle university of tennessee knoxville this thesis is brought to you for free and open access by the graduate school at trace. Research article alloxan induced diabetes mellitus in.
Aqueous extract of maerua oblongifolia rootst exhibited significant antihyperglycemic activities in alloxan induced diabetic rats. Red kidney beans was investigated for its effects in alloxan induced diabetic rats. The alloxan induced diabetic rats were grouped into three groups containing at least 5 rats in each group. After an overnight fast, the rats were injected single dose 125mgkg of freshly prepared 5% solution of alloxan monohydrate in 0. Alloxan monohydrate is used to induce diabetes mellitus in albino rats in the dose of 120mgkg i. Anticoagulant activity of averrhoa bilimbi linn in normal. Anti diabetic and hypolipidaemic properties of ginger zingiber officinale in streptozotocin induced diabetic rats volume 96 issue 4 zainab m. Diabetes was induced in wistar rats by single intraperitoneal administration of alloxan monohydrate 150 mgkg. The experimental animals were grouped into five groups ae of. Streptozotocin use in mice and rats version 1 date of publication. Group a served as the control and received 1 mlkg body weight of 5% ethanol being solvent used, group b received 1 ml alloxan. Glycemic effect of honey on alloxaninduced diabetes and with concomitant administration of fructose was studied in male rats of the wistar strain. Diabetes was induced in wistar albino rats by intraperitoneal injection of alloxan 120 mgkg bw once.
Although their cytotoxicity is achieved via different pathways, their mechanisms of beta cell selective action are identical. View the article pdf and any associated supplements and figures for a period of 48 hours. Thirty 30 adults male wistar rats were randomly divided into six 6 groups of five 5 each based on their body weight. Anti diabetic effect of cherries in alloxan induced. Indeed, the essential oil of rosescented geranium leaves was prepared and their antioxidant activities as well as their hypoglycemic effects were studied. Original article rat model of foodinduced nonobesetype. Antihyperglycemic and antihyperlipidemic activity of.
Hence, the present study undertakes the investigation of possible hypoglycemic and antioxidant effects of pelargonium graveolens leaves in alloxan induced diabetic rats. The mechanisms of alloxan and streptozotocininduced diabetes. Twenty four albino rats were randomly allocated into four groups ad of six rats each such that group a diabetes control received 0. Alloxaninduced diabetic thermal hyperalgesia, prophylaxis. Antidiabetic drugs in combination with hydroxychloroquine. Marked degenerations of the islets of langerhans was observed in pancreas of alloxan induced diabetic rats, whereas, histological examination of the pancreas of. The present study was carried out to evaluate the antidiabetic effect of psidium guajava leaves extract and to study the activities of hexokinase, aldolase and phosphor glucoisomerase, and gluconeogenic enzymes such asglucose6phosphatase and. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal, intravenous and. The hemimandibles were removed and submitted to radiographical and histopathological procedures. Analysis of certain biochemical indices on alloxan induced. Biochemical and haematological effects of the leaf extract. The present study aimed to investigate and compare the hypoglycemic and antilipidemic effects of kombucha and black tea, two natural drinks commonly consumed around the world, in surviving diabetic rats. Pooja 1, mohemmed sadiq 2 1sree vidyanikethan college of pharmacy, sree sainath nagar, tirupati, a.
Graded doses 200 mgkg and 400 mgkg of ethanol extract of plectranthus amboinicus were studied in both normal and alloxan induced. The anti diabetic activity of murva may be by any one of the above said mechanism or by both this mechanism and so might be of value in diabetes treatment. Cronicon open access ec pharmacology and toxicology. The current study sought to investigate the capacities of single and combinatorial herbal formulations of leaf extracts of acanthus montanus, asystasia gangetica, emilia coccinea, and hibiscus rosasinensis to reverse hyperglycemia and dyslipidemia in alloxan induced diabetic male rats. Antidiabetic activity of hibiscus syriacus on alloxan. Pdf silymarin increases antioxidant enzymes in alloxan. Rats were administered 200 mgkgday and 500 mg kgday p. Alloxan is a toxic glucose analogue, which selectively destroys insulinproducing cells in the pancreas that is, beta cells when administered to rodents and many other animal species. This study aims to investigate the therapeutic effects of the aqueous extract of clitoria ternatea linn. Fresh leaves of the plant were collected from their local habitat in the university of nigeria, nsukka environment. The mechanism of alloxan and streptozotocin action in b. Antidiabetic activity of hibiscus syriacus on alloxan induced diabetic rats kanjeri nirosha 1, m. Antidiabetic activity of leaves of jatropha curcus l.
The effects of alloxan on the histology of the pancreas, thyroid and adrenal glands of the white rat julien l. Rats with blood glucose levels above 250 mgdl were considered diabetic 30 and selected for the study. Normal as well as diabetic rats were divided into groups n6 receiving different treatments. Alloxaninduced diabetes triggers the development of. The effect of aepe leaf extract on blood glucose, insulin, hemoglobin and glycosylated hemoglobin, serum lipid profile, liver glycogen and protein were measured in the diabetic rats. The rats randomly selected were divided into six 6 groups of five 5 rats per group.
Anion gap toxicity in alloxan induced type 2 diabetic rats. Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals. It has been successfully induced in a variety of animal species. Thirty nondiabetic control rats nc and 30 untreated diabetic ud rats were divided into three subgroups sacrificed after 6, 14, or 26 weeks. Medicinal plants have been used in the treatment of some diseases like diabetes. Diabetes was induced by administering a single dose of alloxan 120 mgkg.
The induction of diabetes was confirmed after the 5th day of alloxan treatment by. The rats are divided into 6 groups and each group con tains 6 rats n 6 as follows. Albino rats each weighing 180230g were divided into 3 equal groups n10 as following. Antidiabetic activity of aqueous extract of leptospermum. Hypoglycemic and antilipidemic properties of kombucha tea. The effects of alloxan on the histology of the pancreas. Diabetes was induced in male wistar rats by the administration of alloxan monohydrate at 100 mgkg of body weight. Alloxan induced diabetic thermal hyperalgesia, prophylaxis and phytotherapeutic effects of rheum ribes l. Blood glucose level and lipid profile of alloxaninduced. Antidiabetic and hypolipidaemic properties of ginger.
Hypoglycemic and antioxidant effects of leaf essential oil. The purpose of this study is to evaluate the effect of ethanolic extract of cherry fruit on alloxan induced diabetic rats. G1 normal rats fed on normal diet, g2 diabetic rats fed on normal diet, and g3 diabetic rats were fed with raw camel milk. Studies on the administration of vernonia amygdalina del. Antidiabetic effect of ipomoea batatas in normal and alloxan induced diabetic rats. This study evaluated the longterm effects of alloxan induced diabetes in rat liver. Stz is less toxic than alloxan and mortality rate of animals is found less by stz than alloxan. In the light of the above data, the objectives of the present study were to evaluate the effect of hcq on blood glucose and lipid profile in alloxan induced diabetic rats and to study its effect on the above parameters in com bination with conventional oral antidiabetic agents. Effect of dme on alloxan induced diabetic rats a total of twenty five 25 diabetic and five 5 normoglycemic rats of both sexes were used.
Raw camel milk properties on alloxaninduced diabetic. The effect of orally administered aqueous extracts 400 mgkg body weight of clitoria ternatea leaves and flowers on serum glucose, glycosylated hemoglobin, and insulin were examined in control and extract. Alloxan diabetes was induced into 20 rats and the rats weighed 125g. Animals were allocated into five groups of rats, two groups, several as control. Antidiabetic effect of ipomoea batatas in normal and. Alloxaninduced diabetes, a common model for evaluating. The study was conducted to evaluate effect of doum fruit extract on some biochemical parameters, including enzyme activities and histopathological changes of pancreas in alloxan induced diabetic rats. Antidiabetic activity of aqueous extract of cinnamomum. Diabetes was induced in wistar rats n 25 by intravenous administration of alloxan 42 mgkg and were analyzed at 1, 3, 6, 9 and 12 months after diabetes induction. Indeed, in rat islets incubated with alloxan the gsh content and gshgssg ratio were decreased malaisse et al. The present study is aimed to gain an insight about the effects of ethanolic extract of boerhavia diffusa l roots against alloxan induced diabetic rats.
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